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AUTODOCK GmbH
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SourceForge net
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DeLano Scientific
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AUTODOCK GmbH
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Schrodinger LLC
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Schrodinger LLC
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AUTODOCK GmbH
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DeLano Scientific
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Image Search Results
Journal: Nucleic Acids Research
Article Title: InterEvol database: exploring the structure and evolution of protein complex interfaces
doi: 10.1093/nar/gkr845
Figure Lengend Snippet: Screen capture to illustrate the interest of the InterEvol PyMol plugin for diving into the structures of complex interfaces interactively with their evolutionary properties. The example focuses on the Rpb4-Rpb7 complex crystallized in both H. sapiens (pdb code:2c35) and S. cerevisiae (pdb code:1y14). The interface coordinates files were downloaded from InterEvol database in which the chains have been renumbered to match the positions in the alignment [R31, N35 and E41 in Rpb4 (2c35) stand for R44, N48 and E54 in the original PDB]. After selecting a small set of positions neighbouring at the interface it is possible to display a restricted view of the multiple sequence alignment for the 2c35 complex. Specific position can then be selected from the alignment panel and focused on in the structural panel allowing a cross talk between both dimensions. A compensatory switch between two positions of Rpb4 to maintain a salt–bridge interaction with an invariant acidic residue of Rpb7 is presented. The pre-computed alignment reveals this coordinated switch between positions 31 and 35. Retrieving the superimposed structures of the 1y14 complex reveals how structural micro-environments can adapt to allow for the plasticity of the interface in response to potentially deleterious sequence changes.
Article Snippet: Furthermore, an
Techniques: Sequencing, Residue
Journal: Cells
Article Title: Modeling Viral Capsid Assembly: A Review of Computational Strategies and Applications
doi: 10.3390/cells13242088
Figure Lengend Snippet: Popular software used for viral capsid assembly.
Article Snippet: ,
Techniques: Software, Polymer